Hybrid-Multiscale Modeling of the E.Coli Bacteria Division Process
Alvaro Ruiz Martinez
Department of Mechanical and Aerospace Engineering
UC San Diego
The complexity of the coupled proteins system, the stochastic effects, the different time scales
for different reactions and the importance of the contraction forces during E.Coli bacteria division
require to develop a 3D-hybrid-multiscale model that allows us to know in detail about the mechanisms
of this phenomenon. The main aim of this work is the creation of a hybrid algorithm that
facilitates to model biological systems at multiple scales (spatial and temporal), providing
high robustness and accuracy. Moreover, the flexibility of being extended to more complex cases
in which the geometry and mechanical characteristics are more complicated (like a dendritic
spine in a dendrite of a neuron) will make it a very powerful tool in biological problems.
Nowadays, designing multiscale models in biological processes is one of the most challenging and
promising tasks in order to know the nature behavior in more detail, therefore, it is worthy to
try to combine the best features of them in order to increase the efficiency of the algorithms.