Protein Folding, Topological Frustration and Biological Function

Dr. Shachi Gosavi
Department of Physics and Center for Theoretical Biological Physics
University of California, San Diego


In order to function most proteins have to fold to a unique three dimensional shape. Thus, the same protein sequence helps in both biological function and protein folding. I will give a brief introduction to protein folding, the priniciple of minimal frustration and the funneled energy landscapes. I will then discuss the interplay of folding and function through the structure of the protein in the context of the beta-trefoil fold family of proteins.