Protein Folding, Topological Frustration and Biological Function
Dr. Shachi Gosavi
Department of Physics and Center for Theoretical Biological Physics
University of California, San Diego
Abstract
In order to function most proteins have to fold to a unique three
dimensional shape. Thus, the same protein sequence helps in both
biological function and protein folding. I will give a brief introduction
to protein folding, the priniciple of minimal frustration and the funneled
energy landscapes. I will then discuss the interplay of folding and function
through the structure of the protein in the context of the beta-trefoil
fold family of proteins.