Computation of Rare Events and its Applications in Biology

Professor Lei Zhang
Beijing International Center for Mathematical Research and Center for Quantitative Biology
Peking University


The dynamics of complex biological systems is often driven by multiscale, rare but important events. In this talk, I will introduce the numerical methods for computing transition states, and then give two examples in distinct biological systems: one is a multiscale stochastic model to investigate a novel noise attenuation mechanism that relies on more noises in different cellular processes to coordinate cellular decisions during embryonic development; the other is a phase field model to study the neuroblast delamination in Drosophila.